Dev104794 2750..2759

نویسندگان

  • Victor D. Varner
  • Celeste M. Nelson
چکیده

Branching morphogenesis is the developmental program that builds the ramified epithelial trees of various organs, including the airways of the lung, the collecting ducts of the kidney, and the ducts of the mammary and salivary glands. Even though the final geometries of epithelial trees are distinct, the molecular signaling pathways that control branching morphogenesis appear to be conserved across organs and species. However, despite this molecular homology, recent advances in cell lineage analysis and real-time imaging have uncovered surprising differences in the mechanisms that build these diverse tissues. Here, we review these studies and discuss the cellular and physical mechanisms that can contribute to branching

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

4.18 Principles of Cathodic Protection

4.18.1 Historical Background 2747 4.18.2 Electrochemical Principles 2748 4.18.2.1 Aqueous Corrosion 2748 4.18.2.2 Cathodic Protection 2748 4.18.2.3 Oxygen Reduction 2749 4.18.2.4 Hydrogen Evolution 2750 4.18.3 Methods of Applying Cathodic Protection 2751 4.18.3.1 Impressed Current Method 2751 4.18.3.2 Sacrificial Anodes 2752 4.18.4 Proof of Protection 2753 4.18.4.1 Steel 2753 4.18.4.2 Other Met...

متن کامل

Globalisation and Labour Supply of Single Female Heads of Households in Malaysia

Globalisation is a process in which interlink between countries in the world has become more intense and the flow of inputs between one country to another is much easier. In the context of the labour market, the inflow of labor input from foreign countries is more relevant, because it has implications on the local labour, especially the females in terms of job opportunities. This paper attempts...

متن کامل

A partial agonist of the A(1)-adenosine receptor selectively slows AV conduction in guinea pig hearts.

The use of full agonists of the A(1)-adenosine receptor (A(1)-ADOR) as antiarrhythmic agents is limited by their actions to cause high-grade atrioventricular (AV) block, profound bradycardia, atrial fibrillation, and vasodilation. It may be possible to avoid these undesired actions by use of partial agonists. We determined the effects of CVT-2759, a potential partial agonist of A(1)-ADORs, on g...

متن کامل

Selective attenuation of isoproterenol-stimulated arrhythmic activity by a partial agonist of adenosine A1 receptor.

BACKGROUND The goal of this study was to examine the hypothesis that a partial agonist of the adenosine A1 receptor (A1AdoR) may cause a greater attenuation of catecholamine-induced ventricular arrhythmic activity than of contractility. METHODS AND RESULTS The effects of CVT-2759 and adenosine, a partial and a full agonist of the A1AdoR, on isoproterenol-stimulated arrhythmic activity and con...

متن کامل

Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.

BACKGROUND We previously demonstrated that defective interdomain interaction between N-terminal (0 to 600) and central regions (2000 to 2500) of ryanodine receptor 2 (RyR2) induces Ca2+ leak in failing hearts and that K201 (JTV519) inhibits the Ca2+ leak by correcting the defective interdomain interaction. In the present report, we identified the K201-binding domain and characterized the role o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014